Nasal cavity and paranasal sinuses adenocarcinomas. Differences between low-grade adenocarcinoma and intestinal-type adenocarcinoma | SpringerLink

Adenocarcinomas arising in the surface epithelium of nasal and paranasal cavities (NPCA) are uncommon. There are 2 types: a) low-grade adenocarcinomas, and b) intestinal-type adenocarcinomas.

We present four cases of NPCA, 3 intestinal-type adenocarcinomas, and 1 low-grade adenocarcinoma. The mean age of patients with intestinal-type adenocarcinomas was 39 years (27-48) and the clinical stage in 2 cases was T-4, and in 1 patient T-1. Tumors from these patients showed high nuclear resolution, marked pleomorphism, and presented more than 20 mitoses per 10 high-resolution fields (HRF). They were treated with surgery and radiotherapy. One patient presented recurrence without metastases. The patients are alive and free of tumor activity 54 months following initial treatment. The patient with low-grade cylindrical cell adenocarcinoma was 55 years old, with T-4 clinical stage treated with surgery and post-surgery radiotherapy. She is still alive after 24 months of follow-up. This series showed that the combination of radiotherapy and post-surgery treatment is a better option for high-grade adenocarcinoma of advanced clinical stage.

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